PIL News

Our multicenter target trial emulation study on Vancomycin-Induced Acute Kidney Injury in Intensive Care Patients was published in Pharmacoepidemiology & Drug Safety, contributing to clarifying the debate on the nephrotoxicity of the widely used antibiotic vancomycin.

Looking ahead, we aim to further apply our target trial emulation pipeline and reuse EHR data to address other knowledge gaps in medication safety.

This study was conducted as part of the RESCUE project funded by ZonMw: Goed Gebruik Geneesmiddelen.

Charlotte Mittendorff and Joanna Klopotowska presented about the ADAPTIC project at two national conferences Topics in Intensive Care and Hospital Pharmacy Annual Meeting. 

Besides informing the audience about the project goals and planning, we also presented the results from our national survey on how CDSS is used in the ICU setting for drug-drug interactions alerting. 

Our mixed methods study on the Ethics of Leveraging Routinely Collected Patient Data for AI Development from the LEAPfROG project was accepted for publication in Journal of Medical Internet Research. We hope to share the link to the open accesss manuscript soon!

We received implementation funding from ZonMw Goed Gebruik Geneesmiddelen to support the translation of findings from the SIMPLIFY and RESCUE studies into practice in Dutch ICUs. This two-year project aims to bring the tools developed in both studies closer to clinical application by establishing the technical and organizational infrastructure necessary for continuous, data-driven medication safety monitoring.

In this project, we are collaborating closely with the National Intensive Care Evaluation Foundation, the Dutch Hospital Pharmacists Association, the Dutch Intensive Care Association, Z-Index (the National Drug Database G-Standaard), and the Royal Dutch Pharmacists Association.

Our study from the LEAPfROG project on identifying a cohort of hospitalized chronic kidney disease patients using electronic health records was published in Clinical Kidney Journal.

Existing e-phenotypes for CKD cohort identification lack consistency with KDIGO-CKD guidelines. This study analyzed EHR data from 108,854 hospitalized adults (2018–23) at Amsterdam University Medical Centre, evaluating six logical rules for CKD cohort selection. The rules, derived from KDIGO-CKD and published studies, identified 17,805 CKD patients (16.4%). The study highlights the need for interdisciplinary collaboration to formalize CKD definitions and adapt them for EHRs, laying the foundation for standardized cohort capture in future EHR-based studies.

The first edition of the Summer School in PharmacoInformatics was successfully concluded!

18 healthcare professionals spent an intensive week enhancing their knowledge and skills in data-driven innovations for medication safety.

The program included: identifying information needs, FAIR principles and quality control on EHR data, data analysis methods (causal and predictive models), development of decision-support systems.

The Summer School in PharmacoInformatics marked an important step in bridging the gap between medical informatics and pharmaceutical care practice.

Joanna Klopotowska participated in study led by the researchers from UMCG about the adoption of antithrombotic stewardship and use of CDSS. The results were published in Plos One.

Our team presented reseach from RESCUE, REMEDY and LEAPfROG studies at the annual meeting of ISPE in Berlin.

Our LEAPfROG study describing an integrated approach for representing knowledge on nephrotoxic potential of drugs published in Drug Safety.

Our stepped-wedge cluster randomised trial on the effect of tailoring CDSS pDDI alerts to the ICU environment was published in The Lancet. Click on the link to read the whole manuscript.

Rachel Murphy and Joanna Klopotowska participated in a systemtic review led by the researchers from UMCG on use of AI in CDSS for medication. The review was published in JAMIA.

Joanna Klopotowska participated in study led by the researchers from UMCG about the adoption of antithrombotic stewardship and use of CDSS. The results were published in Plos One.

PhD Defense: Potential drug-drug interactions in the intensive care

A fantastic day for Tinka Bakker! She defended her PhD thesis pertaining to the SIMPLIFY study on the 7th December.

Her thesis showed that 40% of the assessed potential drug-drug interactions (pDDIs) in the intensive care (ICU) were considered not clinically relevant. The use of computerized decision support systems can support clinicians to enhance medication safely, by showing pDDI alerts to warn about pDDIs. Tailoring pDDI alerts to the ICU setting reduced exposure to clinically relevant pDDIs for ICU patients, improved patient monitoring, and decreased ICU length of stay.

The early findings from our project on the diagnosis of vancomycin-induced acute kidney injury were accepted for publication in the findings track and lighting round presentation at the prestigious machine learning conference ML4H.

The early findings paper is now published here: [2311.09137] Causal prediction models for medication safety monitoring: The diagnosis of vancomycin-induced acute kidney injury (arxiv.org)

We presented the results of the SIMPLIFY intervention study at two ICCU conferences in the Netherlands : Topics in ICU 2023 and Translational Intensive Care Medicine Amsterdam.”

June 2023

July 2023

August 2023

We presented about the SIMPLIFY and RESCUE study at the NICE Discussion day 2023.

Our study “Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data.” has been published in Clinical Kidney Journal

Our study “Adverse drug events caused by three high-risk drug-drug interactions in patients admitted to intensive care units: a multicentre retrospective observational study.” published in British Journal of Clinical Pharmacology

March 2023

February 2023

Our paper “Drug-related causes attributed to acute kidney injury and their documentation in intensive care patients” has been published in Journal of Critical Care.

Our systematic review “Electronic health record-based prediction models for in-hospital adverse drug event diagnosis or prognosis” has been published in JAMIA

Our scoping review “Adverse drug event detection using natural language processing: A scoping review of supervised learning methods” has been published in PLOS One.

March 2022

We are very excited to share that “LEveraging real-world dAta to optimize PharmacotheRapy outcomes in multimOrbid patients by using machine learning and knowledGe representation methods” – the LEAPfROG project, has been granted funding by the Dutch Research Council (NWO).

26-03-2022: SIMPLIFY Study featured in ZonMW GGG magazine

SIMPLIFY Study has been selected to be featured in the ZonMW magazine about 10 years of Goed Gebruik Geneesmiddelen (GGG) programme. For this magazine ZonMW funded studies perceived as most interesting, successful and/or promising have been selected. The results of the SIMPLIFY Study will be presented at the GGG Conference on 31st of March 2022. 

9-3-2022: Our abstract selected for oral presentation at ERA Congress

Our abstract on “Acute Kidney Injury and exposure to nephrotoxic drugs in critically ill patients – a report from the multicenter RESCUE project in the Netherlands” has been selected for oral presentation at the 59th European Renal Association (ERA) Congress in Paris from 19-22 March 2022.